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KMID : 1171820070220030089
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Journal of Environmental and Sanitary Engineering
2007 Volume.22 No. 3 p.89 ~ p.96
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A Study on Contents of Arti-impotence drug/drug-like compounds in Food
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Hong Hae-Geun
Bang Sun-Jae
Park Kwang-Hee
Lee In-Sook
Park Min-Jung
Park Jeong-Hwa
Kim Jong-Chan
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Abstract
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To det ermine 8 anti-impotence drug/drug-like compounds such as sildenafil, vardenafil, tadalafil, homosildenafil, hydroxyhomosildenafil, aminotadalafil, pseudovardenafil and hongdenafil in foods, simultaneously, high performance liquid chromatograrhy(HPLC) and liquid chromatograthy-mass spectrometry (LC/MS) were used.The HPLC/UV analysis was performed on a column of capcellpak C₁? with 0,1 % sodium-1-hexansulfonate in 0.2M ammonium formate/acetonitrile as a mobile phase. Mass spectra of the compounds by LC/MS were investigated with SCAN mode(Mass range and Fragment voltage) and SIM (Selected Ion Monitoring) mode (Ion target and Fragment voltage).The results follow as; 1. The HPLC/UV analysis was detected from 5 out of 63 samples. The content of sildenafil was in the range of 32.80 ppm~60,13 ppm from 4 out of 5 samples, The contents of sildenafil, vardenafil, homosildenafil were in the range 47,14 ppm from lout of 5 samples. 2. The conformed result of LC/MS was equal of detected from 5 out of 63 samples in HPLC/UV analysis. An easily available, simultaneous determination of 8 standards in adulterated health related foods was established by using a combination of LC/MS methods.
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KEYWORD
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anti-impotence drug/drug-like compounds, HPLC/UV, LC/MS, foods
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